Genetic+Disorder+Information+Brochure

Scientific Name: Retinoblastoma Common bame: Cancer of the Retina

Intiated by a mutation that causes inactivation of the RBI genes and it's copy. The gene codes for the retinoblastoma protein.¹ Retinoblastoma occurs mostly in childhood. 87 percent of children with the disease die but most of these deaths are caused by lack of medical care. 90% of those with the disease have no family history of it. The disease occurs equally in boys and girls. The disease also occurs equally in all races and ethinecity. The disease is rare as it is diagnosed 200 to 300 children each year. Some signs of retino blastoma can include crossed eyes, white glow of eye in dim lighting and a white pupil in a photograph

Affected Eye usually removed before cancer spreads. Chemotherapy is now the treatment of choice. Radiotherapy usually used as last resort because it can secondary cacerous growths later on, elimination of healthy cells that are nearby the affected area, and causing the growth plates around the eye to deform. The cancer can easily spread to the brain. 2 0ut 0f 3 people affected have unilateral (in one eye) retinoblastoma and 1 ot of 3 have bilateral (in both eyes) retinoblastoma.



Works Cited http://en.wikipedia.org/wiki/Retinoblastoma¹ http://www.retinoblastoma.net/ __ http://www.ncbi.nlm.nih.gov/pubmed/3306547 __ [|:http://www.ncbi.nlm.nih.gov/pubmed/3306547 www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics_for_retinoblastoma_37.asp]