Down's+Syndrome+CLM

 ·   Also called Trisom21  ·   Jerome Lejeune discovered DS in 1959  ·     Named after John Langdon Down a British doctor who first identified the condition in 1866 **__ Symptoms __**  ·   Decreased muscle tone at birth, asymmetrical or odd-shaped skull, round head with flat area at the back of the head, small skull, slanting eyes, small mouth with protruding tongue, broad short hands, single crease in the palms, retarded growth and development, delayed mental and social skills(mental retardation).  ·   About every part of your body  ·   Common ones are: hearing problems, thyroid problems, eye problems, congenital heart disease, seizure disorders, bone, muscle, nerve, joint problems, and many others.  ·   Hearing problems: <span style="FONT-SIZE: 11pt; FONT-FAMILY: Wingdings; mso-fareast-font-family: Wingdings; mso-bidi-font-family: Wingdings"> §     66% to 89% of children with down’s have hearing loss of greater than 15 to 20 decibels in at least one ear. <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Wingdings; mso-fareast-font-family: Wingdings; mso-bidi-font-family: Wingdings"> §    This happens because people with the disorder have external ear and the bones in middle and inner develop differently. <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   It is treatable but you can not cure it. <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·     People who have it have to live with it for the rest of their lives. <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   But scientists are continuing to research in hope to find a cure. <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   Some kids with Down’s syndrome may have a lot of medical attention, while others lead a healthy life <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">**__ How many people have it? __**   <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·    Effects every 1 in every 800 baby’s <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·     can be detected before the child is born <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">**__ Sex and Race Effects? __**   <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·    Both sexes are affected equally <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·     Greater expectance for whites and less than Hispanics <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">**__ Gene or chromosome it is on: __** <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   it is chromosome 21 <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   In Trisomy21 the presence of an extra set of genes leads to over expression of the involved genes, which could increase the production of certain products <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   Only a small portion of the 21st chromosome actually needed to be triplicate to get the effects seen in Down syndrome, which is known as Down’s Syndrome Critical Region <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"><span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> ·   21st chromosome might actually hold 200 to 500 genes <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> <span style="FONT-SIZE: 11pt; FONT-FAMILY: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol"> <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">o   <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">Picture: <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://www.thespeciallife.com/images/downs-syndrome-boy.jpg <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">
 * __ <span style="FONT-FAMILY: 'Times New Roman', Times, serif">Name/Named After/Discovered By   __**
 * __ <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">Effects/Cure   __**

Citations: <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://en.wikipedia.org/wiki/Down_syndrome <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">, <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://www.querycat.com/faq/e1eaf88af64a642100fe3a0724623c16 <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> , <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://www.mamashealth.com/syndrome/downsyn.asp <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> , <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://kidshealth.org/parent/medical/genetic/down_syndrome.html <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> , <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://down-syndrome.emedtv.com/down-syndrome/down-syndrome-effects.html <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> , <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://cat.inist.fr/?aModele=afficheN&cpsidt=2572983 <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> , <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif">http://www.ds-health.com/trisomy.htm <span style="FONT-SIZE: 70%; FONT-FAMILY: 'Times New Roman', Times, serif"> ,